PR: Two new Psilmi patent applications

March 28th, 2026

Stardots files two new patent applications advancing objective measurement in psychiatry

Stardots Expands Psilmi® Platform with Two U.S. Patent Filings, Advancing Objective Measurement in Psychiatry

Stardots today announced the filing of two new U.S. patent applications, strengthening the IP foundation of Psilmi®, its multi-indication SaMD platform for physiology-based measurement in CNS disorders.

The filings expand Psilmi’s capability to capture and translate neurophysiological signals into actionable biomarkers for clinical decision support and drug development.

New IP covers:

🔹 Pupil Regulation Biomarkers
Light-evoked pupil response modeling generating ~50 markers of autonomic regulation, arousal, and cognitive load

→ Enables objective readouts of neurophysiology and treatment dynamics

🔹 Visual Search Pattern Biomarkers
Eye-tracking-based Go/No-Go paradigm quantifying attention, inhibition, and search efficiency

→ Enables scalable assessment of executive function

Impact:
Psilmi® introduces a measurement layer for psychiatry (e.g., ADHD, depression, anxiety, and autism) , supporting:

  • Patient stratification in heterogeneous populations
  • Earlier, objective detection of treatment response
  • Treatment selection and titration strategies
  • Improved clinical trial design and probability of success

Example: Enabling differentiation of patient subgroups more likely to respond to stimulant vs. non-stimulant treatments in ADHD.

Why this matters:
Psychiatry remains one of the largest therapeutic areas without objective measurement, driving variability in outcomes and inefficiencies in drug development.

“You can’t optimize what you can’t measure — and psychiatry has lacked that layer.”

Psilmi® is designed to integrate into both clinical trials and real-world care, enabling more precise, data-driven decisions across CNS..

Stardots collaborates with Uppsala University, Karolinska Institutet, and Harvard Medical School, and is supported by IP partners at Nutter McClennen & Fish LLP. Stardots — Precision Psychiatry, Built on Physiology.

#DigitalBiomarkers #SaMD #Pupillometry #CNS #ADHD #Depression #AIinHealthcare #PrecisionPsychiatry #Neurotechnology